Fruit resources represent significant assets for national dietary sustenancerural economic revitalization. Nepal, possessing ample natural diversity, has abundant fruit resources, notably Prunus cerasifera Ehrh.Prunus persica (L.) Batsch, distributed from the eastern to western regions of the country. We assessed the ethnobotanical significancecurrent utilization of these speciesproposed a sustainable usage roadmap. An ethnobotanical survey was conducted across 54 districts of Nepal, encompassing data from 775 respondents. P. cerasiferaP. persica were utilized in 812 major categories, respectively. The total use reports for P. cerasifera were 1441,P. persica was 1867. The fidelity level was highest (100%) for fruit use for P. persica99.4% for P. cerasifera. The generalized linear model (GLM) Poisson showed that P. persica was significantly dependent on ageoccupation; however, P. cerasifera was not dependent on these variables. We conclude that to optimize the utilization of P. cerasiferaP. persica, product development initiatives such as juice, wine,alcohol production should be prioritized. These value-added products can enhance economic benefits while ensuring the sustainable use of these species.